Delivery of Antimicrobials in Root-canal Treatment

Addition of antibiotics to dental cement

Mineral Trioxide Aggregate (MTA) is a dental cement used in root canal obturations. It is of great interest to add antibiotics to MTA in order to prevent recurring infections after obturation. However, many antibiotics have been shown to degrade the mechanical properties of the cement. By using a special salt form of the antibiotic, we were able to retain both antimicrobial effectiveness (Figure 1) and mechanical stability. In this study, White Portland Cement (WPC), a representative material, was used in place of MTA. Future studies will involve validating the results using the MTA material.

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Figure 1. 0.12% Antibiotic in Portland Cement sample. This figure demonstrates the ability of the modified cement to prevent the growth of E. Faecalis.